Cdk4^tm1Kiyo
Targeted Allele Detail

Summary

• Symbol: Cdk4^tm1Kiyo
• Name: cyclin dependent kinase 4; targeted mutation 1, Hiroaki Kiyokawa
• MGI ID: MGI:2149587
• Synonyms: CDK4-
• Gene: Cdk4 Location: Chr10:126899404-126903157 bp, + strand Genetic Position: Chr10, 74.5 cM, cytoband D3
• Alliance: Cdk4^tm1Kiyo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57854
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin cassette replaced a 3' portion of exon 1 and all of exons 2 - 5. Western blot analysis on extracts derived from fibroblasts of homozygous mice detected no encoded protein. (J:57854)

Expression

In Mice Carrying this Mutation:	37 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Cdk4^tm1Kiyo

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdk4 Mutation: 58 strains or lines available

References

• Original: J:57854 Tsutsui T, et al., Targeted disruption of CDK4 delays cell cycle entry with enhanced p27(Kip1) activity. Mol Cell Biol. 1999 Oct;19(10):7011-9
• All: 23 reference(s)