Irs3^tm1Lhd
Targeted Allele Detail

Summary

• Symbol: Irs3^tm1Lhd
• Name: insulin receptor substrate 3; targeted mutation 1, Gustav E Lienhard
• MGI ID: MGI:2149647
• Synonyms: IRS-3^-, IRS3-
• Gene: Irs3 Location: Chr5:137641294-137643976 bp, - strand Genetic Position: Chr5, 76.59 cM, cytoband G2
• Alliance: Irs3^tm1Lhd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:55667
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• A neomycin resistance cassette disrupted the coding region of the gene. (J:55667)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Irs3 Mutation: 17 strains or lines available

References

• Original: J:55667 Liu SC, et al., Insulin receptor substrate 3 is not essential for growth or glucose homeostasis. J Biol Chem. 1999 Jun 18;274(25):18093-9
• All: 4 reference(s)