Hes1^tm1Fgu
Targeted Allele Detail

Summary

• Symbol: Hes1^tm1Fgu
• Name: hes family bHLH transcription factor 1; targeted mutation 1, Francois Guillemot
• MGI ID: MGI:2149672
• Synonyms: Hes1-
• Gene: Hes1 Location: Chr16:29883259-29886614 bp, + strand Genetic Position: Chr16, 21.09 cM
• Alliance: Hes1^tm1Fgu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:30431
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin resistance cassette replaced the first three exons including sequences encoding the bHLH region of HES1. Northern blot analysis did not detect transcript in E9.5 homozygous mutant embryos. (J:30431)

Expression

In Mice Carrying this Mutation:	386 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	25 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hes1 Mutation: 23 strains or lines available

References

• Original: J:30431 Ishibashi M, et al., Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects. Genes Dev. 1995 Dec 15;9(24):3136-48
• All: 74 reference(s)