Hes5^tm1Fgu
Targeted Allele Detail

Summary

• Symbol: Hes5^tm1Fgu
• Name: hes family bHLH transcription factor 5; targeted mutation 1, Francois Guillemot
• MGI ID: MGI:2149674
• Synonyms: Hes5-
• Gene: Hes5 Location: Chr4:155045380-155046828 bp, + strand Genetic Position: Chr4, 86.01 cM
• Alliance: Hes5^tm1Fgu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:54662
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin resistance cassette replaced 724 bp of sequence including the region that encodes the bHLH domain (Met1 to Ala76). (J:62024)

Expression

In Mice Carrying this Mutation:	99 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hes5 Mutation: 16 strains or lines available

References

• Original: J:54662 Ohtsuka T, et al., Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation. EMBO J. 1999 Apr 15;18(8):2196-207
• All: 35 reference(s)