Slc2a4^tm1Mch
Targeted Allele Detail

Summary

• Symbol: Slc2a4^tm1Mch
• Name: solute carrier family 2 (facilitated glucose transporter), member 4; targeted mutation 1, Maureen J Charron
• MGI ID: MGI:2149725
• Synonyms: GLUT-4 null
• Gene: Slc2a4 Location: Chr11:69833365-69839014 bp, - strand Genetic Position: Chr11, 42.93 cM, cytoband C-E1
• Alliance: Slc2a4^tm1Mch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:49328
• Parent Cell Line: WW6 (ES Cell)
• Strain of Origin: STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into exon 10 of the gene, disrupting expression. Loss of expression was shown by Northern and Western blots of skeletal muscle. (J:49328)

Disease models

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc2a4 Mutation: 35 strains or lines available

References

• Original: J:49328 Katz EB, et al., Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4 [see comments]. Nature. 1995 Sep 14;377(6545):151-5
• All: 25 reference(s)