Irs4^tm1Lhd
Targeted Allele Detail

Summary

• Symbol: Irs4^tm1Lhd
• Name: insulin receptor substrate 4; targeted mutation 1, Gustav E Lienhard
• MGI ID: MGI:2149726
• Synonyms: Irs4-, IRS-4 null
• Gene: Irs4 Location: ChrX:140493994-140508213 bp, - strand Genetic Position: ChrX, 62.43 cM
• Alliance: Irs4^tm1Lhd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:59964
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced the entire coding sequence of the gene except for 457 bp at the 3' end. Reverse transcription-PCR detected no mRNA expression in brain, skeletal muscle, kidney, or liver of homozygous mutant mice. (J:59964)

Expression

In Mice Carrying this Mutation:	12 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Irs4 Mutation: 5 strains or lines available

References

• Original: J:59964 Fantin VR, et al., Mice lacking insulin receptor substrate 4 exhibit mild defects in growth, reproduction, and glucose homeostasis. Am J Physiol Endocrinol Metab. 2000 Jan;278(1):E127-33
• All: 4 reference(s)