Jun^tm2.1Wag
Targeted Allele Detail

Summary

• Symbol: Jun^tm2.1Wag
• Name: jun proto-oncogene; targeted mutation 2.1, Erwin F Wagner
• MGI ID: MGI:2149755
• Synonyms: c-jun^AA, JunAA
• Gene: Jun Location: Chr4:94937273-94940459 bp, - strand Genetic Position: Chr4, 43.34 cM, cytoband C5-C7
• Alliance: Jun^tm2.1Wag page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:53481
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: A floxed PGK-betageo selection cassette was inserted into position -360 of the 5' UTR of the gene. In addition, serine codons 63 and 73 were changed to alanines (S63A and S73A) by site directed PCR-based mutagenesis. In this allele the floxed PGK-betageo cassette was removed by pronuclear injection of a cre-expressing plasmid. (J:53481)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Jun^tm2.1Wag

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Jun Mutation: 12 strains or lines available

References

• Original: J:53481 Behrens A, et al., Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation. Nat Genet. 1999 Mar;21(3):326-9
• All: 13 reference(s)