Gipr^tm1Yse
Targeted Allele Detail

Summary

• Symbol: Gipr^tm1Yse
• Name: gastric inhibitory polypeptide receptor; targeted mutation 1, Yutaka Seino
• MGI ID: MGI:2149964
• Synonyms: GIPR-
• Gene: Gipr Location: Chr7:18889986-18900052 bp, - strand Genetic Position: Chr7, 9.46 cM
• Alliance: Gipr^tm1Yse page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:59087
• Parent Cell Line: CGR8 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin cassette replaced exons 4 and 5 of the gene, which encode the N-terminal extracellular region of the protein. No functional protein product is expressed from this allele. (J:59087)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gipr Mutation: 30 strains or lines available

References

• Original: J:59087 Miyawaki K, et al., Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout mice. Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):14843-7
• All: 45 reference(s)