Aqp3^tm1Ask
Targeted Allele Detail

Summary

• Symbol: Aqp3^tm1Ask
• Name: aquaporin 3; targeted mutation 1, Alan S Verkman
• MGI ID: MGI:2150021
• Synonyms: AQP3-
• Gene: Aqp3 Location: Chr4:41092724-41098183 bp, - strand Genetic Position: Chr4, 20.94 cM, cytoband B1
• Alliance: Aqp3^tm1Ask page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:61675
• Parent Cell Line: CB1-4 (ES Cell)
• Strain of Origin: C57BL/6J x (Rb(11.16)2H x Rb(16.17)32Lub)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1.3kb neomycin resistance cassette replaced parts of exons 2 and 3 of the gene. Northern blots of kidneys from homozygous mutant mice had no detectable Aqp3 transcript. Immunofluorescence analysis of fixed frozen kidney sections from homozygous mutant mice had no detectable Aqp3 protein. (J:61675)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aqp3 Mutation: 28 strains or lines available

References

• Original: J:61675 Ma T, et al., Nephrogenic diabetes insipidus in mice lacking aquaporin-3 water channels. Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4386-91
• All: 37 reference(s)