Otx2^tm2Asim
Targeted Allele Detail

Summary

• Symbol: Otx2^tm2Asim
• Name: orthodenticle homeobox 2; targeted mutation 2, Antonio Simeone
• MGI ID: MGI:2150146
• Synonyms: Otx2^lambda
• Gene: Otx2 Location: Chr14:48894238-48905101 bp, - strand Genetic Position: Chr14, 25.36 cM
• Alliance: Otx2^tm2Asim page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71034
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The insertion disrupts the 3' UTR of the gene. It introduces a short piece of bacteriophage lambda DNA into the gene as a tag for molecular detection. A neomycin cassette was also inserted 3' to the lambda DNA tag. (J:71034)

Expression

In Mice Carrying this Mutation:	72 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Otx2 Mutation: 50 strains or lines available

References

• Original: J:71034 Boyl PP, et al., Forebrain and midbrain development requires epiblast-restricted Otx2 translational control mediated by its 3' UTR. Development. 2001 Aug;128(15):2989-3000
• All: 2 reference(s)