Dpp4^tm1Nwa
Targeted Allele Detail

Summary

• Symbol: Dpp4^tm1Nwa
• Name: dipeptidylpeptidase 4; targeted mutation 1, Nicolai Wagtmann
• MGI ID: MGI:2150161
• Synonyms: CD26-, DP-IV-
• Gene: Dpp4 Location: Chr2:62160417-62242575 bp, - strand Genetic Position: Chr2, 35.85 cM, cytoband C2-D
• Alliance: Dpp4^tm1Nwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62709
• Parent Cell Line: BL/6-III (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a 2.3kb segment of the gene, including part of the promoter and all of exons 1 and 2, which encode the cytoplasmic and transmembrane domains of the protein. Flow cytometric analysis of thymocytes from homozygous mutantt mice stained with anti-Dpp4 mAb showed no protein expression. ELISA measurements showed undetectable protein concentrations in the plasma of homozygous mutant mice. (J:62709)

Expression

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dpp4 Mutation: 73 strains or lines available

References

• Original: J:62709 Marguet D, et al., Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6874-9
• All: 39 reference(s)