Hoxa4^tm1Mrc
Targeted Allele Detail

Summary

• Symbol: Hoxa4^tm1Mrc
• Name: homeobox A4; targeted mutation 1, Mario R Capecchi
• MGI ID: MGI:2150391
• Synonyms: hoxa-4^-
• Gene: Hoxa4 Location: Chr6:52166662-52168683 bp, - strand Genetic Position: Chr6, 25.4 cM
• Alliance: Hoxa4^tm1Mrc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:19219
• Parent Cell Line: CC1.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced 1.5 kb of genomic DNA between sequences that encode the recognition helix of the homeodomain and a point 3' to the stop codon. No mRNA was detected by RT-PCR analysis on RNA derived from E12.5 embryos. (J:19219)

Expression

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxa4 Mutation: 9 strains or lines available

References

• Original: J:19219 Kostic D, et al., Targeted disruptions of the murine Hoxa-4 and Hoxa-6 genes result in homeotic transformations of components of the vertebral column. Mech Dev. 1994 Jun;46(3):231-47
• All: 1 reference(s)