Hoxa5^tm1Rob
Targeted Allele Detail

Summary

• Symbol: Hoxa5^tm1Rob
• Name: homeobox A5; targeted mutation 1, Elizabeth J Robertson
• MGI ID: MGI:2150397
• Synonyms: Hoxa5-
• Gene: Hoxa5 Location: Chr6:52178768-52181437 bp, - strand Genetic Position: Chr6, 25.4 cM
• Alliance: Hoxa5^tm1Rob page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:15576
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Insertion of a neomycin resistance cassette into exon 2 disrupted sequences that encode the DNA binding homeodomain. Northern analysis using an exon 2 probe detected novel transcripts and no wild-type transcripts in lung and kidney of homozygous mutant mice. (J:71563)

Expression

In Mice Carrying this Mutation:	217 assay results
In Structures Affected by this Mutation:	23 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Hoxa5^tm1Rob

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hoxa5 Mutation: 28 strains or lines available

References

• Original: J:15576 Jeannotte L, et al., Specification of axial identity in the mouse: role of the Hoxa-5 (Hox1.3) gene. Genes Dev. 1993 Nov;7(11):2085-96
• All: 26 reference(s)