Eya1^tm1Rilm
Targeted Allele Detail

Summary

• Symbol: Eya1^tm1Rilm
• Name: EYA transcriptional coactivator and phosphatase 1; targeted mutation 1, Richard Maas
• MGI ID: MGI:2150426
• Synonyms: Eya1-
• Gene: Eya1 Location: Chr1:14239178-14380459 bp, - strand Genetic Position: Chr1, 4.31 cM
• Alliance: Eya1^tm1Rilm page

Spectrum of abnormalities of great artery patterning in mice with null mutation of one or both copies of Six1^tm1Mair and Eya1^tm1Rilm

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57313
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin cassette replaced exons 10-13, encoding 153 residues of the Eya domain. (J:57313)

Disease models

Expression

In Mice Carrying this Mutation:	195 assay results
In Structures Affected by this Mutation:	55 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Eya1 Mutation: 56 strains or lines available

References

• Original: J:57313 Xu PX, et al., Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia. Nat Genet. 1999 Sep;23(1):113-7
• All: 29 reference(s)