Oat^tm1Dva
Targeted Allele Detail

Summary

• Symbol: Oat^tm1Dva
• Name: ornithine aminotransferase; targeted mutation 1, David Valle
• MGI ID: MGI:2150441
• Gene: Oat Location: Chr7:132159207-132178127 bp, - strand Genetic Position: Chr7, 76.3 cM
• Alliance: Oat^tm1Dva page

Retinal histopathology of Oat^tm1Dva/Oat^tm1Dva mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:29269
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin cassette was inserted into exon 3 (codon 40 of the 439 codon reading frame) of the gene. This insertion truncated the peptide 13 amino acid residues downstream of the cleavage site for the N-terminal mitochondrial targeting sequence. Southern blots showed production of a truncated protein in mutant mice, and functional assasys showed lack of enzymatic activity of the truncated protein. (J:29269)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Oat Mutation: 21 strains or lines available

References

• Original: J:29269 Wang T, et al., Mice lacking ornithine-delta-aminotransferase have paradoxical neonatal hypoornithinaemia and retinal degeneration. Nat Genet. 1995 Oct;11(2):185-90
• All: 6 reference(s)