Hoxa13^tm1Ipc
Targeted Allele Detail

Summary

• Symbol: Hoxa13^tm1Ipc
• Name: homeobox A13; targeted mutation 1, I Pierre Chambon
• MGI ID: MGI:2150506
• Gene: Hoxa13 Location: Chr6:52235833-52237865 bp, - strand Genetic Position: Chr6, 25.41 cM
• Alliance: Hoxa13^tm1Ipc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:36214
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin cassette was inserted into sequences encoding the homeobox domain; this mutation generates a disruption of the protein sequence after the 34th amino acid, corresponding to the second alpha helix of the homeodomain. (J:36214)

Expression

In Mice Carrying this Mutation:	45 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxa13 Mutation: 29 strains or lines available

References

• Original: J:36214 Fromental-Ramain C, et al., Hoxa-13 and Hoxd-13 play a crucial role in the patterning of the limb autopod. Development. 1996 Oct;122(10):2997-3011
• All: 11 reference(s)