Fgfr1^tm1Led
Targeted Allele Detail

Summary

• Symbol: Fgfr1^tm1Led
• Name: fibroblast growth factor receptor 1; targeted mutation 1, Philip Leder
• MGI ID: MGI:2150650
• Synonyms: Fgfr-1^ex4
• Gene: Fgfr1 Location: Chr8:26008808-26067819 bp, + strand Genetic Position: Chr8, 14.12 cM
• Alliance: Fgfr1^tm1Led page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:22118
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin cassette disrupted exon 4 of the gene, introducing stop codons in the three reading frames and truncating the coding sequence immediately after the Ig2 domain. (J:22118)

Disease models

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgfr1 Mutation: 223 strains or lines available

References

• Original: J:22118 Deng CX, et al., Murine FGFR-1 is required for early postimplantation growth and axial organization. Genes Dev. 1994 Dec 15;8(24):3045-57
• All: 3 reference(s)