Hoxc4^tm1Mrc
Targeted Allele Detail

Summary

• Symbol: Hoxc4^tm1Mrc
• Name: homeobox C4; targeted mutation 1, Mario R Capecchi
• MGI ID: MGI:2150683
• Gene: Hoxc4 Location: Chr15:102927366-102945278 bp, + strand Genetic Position: Chr15, 58.08 cM
• Alliance: Hoxc4^tm1Mrc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:34198
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin cassette was inserted into the XhoI site at nucleotide 10 of the sequences encoding the homeobox domain. Immunohistochemistry studies failed to detect any protein in hemisected E12.5 homozygous embryos. (J:34198)

Expression

In Mice Carrying this Mutation:	26 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxc4 Mutation: 9 strains or lines available

References

• Original: J:34198 Boulet AM, et al., Targeted disruption of hoxc-4 causes esophageal defects and vertebral transformations. Dev Biol. 1996 Jul 10;177(1):232-49
• All: 1 reference(s)