Ppp3ca^tm1Jse
Targeted Allele Detail

Summary

• Symbol: Ppp3ca^tm1Jse
• Name: protein phosphatase 3, catalytic subunit, alpha isoform; targeted mutation 1, Jonathan G Seidman
• MGI ID: MGI:2150749
• Synonyms: Aalpha-, CNAa-, CnA alpha (_), CnA-alpha-
• Gene: Ppp3ca Location: Chr3:136375885-136643488 bp, + strand Genetic Position: Chr3, 63.34 cM
• Alliance: Ppp3ca^tm1Jse page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71750
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin cassette was inserted into the exon encoding nucleotides 572 - 717 of the mRNA sequence of the gene. This exon encodes part of the catalytic domain of the protein. Western blots of T cell extracts from homozygous mutant mice showed no detectable peptide. (J:71750)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ppp3ca Mutation: 55 strains or lines available

References

• Original: J:71750 Zhang BW, et al., T cell responses in calcineurin A alpha-deficient mice. J Exp Med. 1996 Feb 1;183(2):413-20
• All: 21 reference(s)