Gnal^tm1Rax
Targeted Allele Detail

Summary

• Symbol: Gnal^tm1Rax
• Name: guanine nucleotide binding protein, alpha stimulating, olfactory type; targeted mutation 1, Richard Axel
• MGI ID: MGI:2151207
• Synonyms: Galphaolf, G-olf^-
• Gene: Gnal Location: Chr18:67221369-67359863 bp, + strand Genetic Position: Chr18, 39.85 cM
• Alliance: Gnal^tm1Rax page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:45534
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A Pgk-neomycin resistance cassette replaced 1.65kb of sequence that includes the first four exons of the gene. RNA in situ hybridization analysis did not detect transcripts in olfactory sensory neurons of 5-day old homozygous mutant mice. Immunohistochemistry analysis showed reduced staining on olfactory bulb sections derived from 5-day old homozygous mutant mice. (J:45534)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gnal Mutation: 27 strains or lines available

References

• Original: J:45534 Belluscio L, et al., Mice deficient in G(olf) are anosmic. Neuron. 1998 Jan;20(1):69-81
• All: 21 reference(s)