Grid2^tpr
Spontaneous Allele Detail

Summary

• Symbol: Grid2^tpr
• Name: glutamate receptor, ionotropic, delta 2; tapdancer
• MGI ID: MGI:2151353
• Synonyms: tpr
• Gene: Grid2 Location: Chr6:63232860-64681307 bp, + strand Genetic Position: Chr6, 29.77 cM
• Alliance: Grid2^tpr page

Mutation origin

• Strain of Origin: B10.D2/nSnJ

Mutation description

• Allele Type: Spontaneous (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The spontaneous tpr mutation was identified at the University of Michigan. RT-PCR revealed that the sequences corresponding to exons 3 and 4 are absent in the encoded transcript. This results in a frame shift leading to premature termination at residue 91 in exon 5. PCR on genomic DNA confirmed that exons 3 and 4 are deleted in this mutant. The predicted truncated protein could not be detected immunologically. (J:84411)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grid2 Mutation: 85 strains or lines available

References

• Original: J:84411 Wang Y, et al., A hot spot for hotfoot mutations in the gene encoding the delta2 glutamate receptor. Eur J Neurosci. 2003 Apr;17(8):1581-90
• All: 1 reference(s)