Hoxb4^tm2Bay
Targeted Allele Detail

Summary

• Symbol: Hoxb4^tm2Bay
• Name: homeobox B4; targeted mutation 2, Baylor College of Medicine
• MGI ID: MGI:2151429
• Synonyms: hoxb-4^s
• Gene: Hoxb4 Location: Chr11:96209093-96212464 bp, + strand Genetic Position: Chr11, 59.83 cM
• Alliance: Hoxb4^tm2Bay page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:4612
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Insertion of a 14 bp oligonucleotide that generates a premature stop codon in the second exon, which encodes the third helix of the homeodomain. (J:4612)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxb4 Mutation: 20 strains or lines available

References

• Original: J:4612 Ramirez-Solis R, et al., Hoxb-4 (Hox-2.6) mutant mice show homeotic transformation of a cervical vertebra and defects in the closure of the sternal rudiments. Cell. 1993 Apr 23;73(2):279-94
• All: 2 reference(s)