Hoxd4^tm1Bhr
Targeted Allele Detail

Summary

• Symbol: Hoxd4^tm1Bhr
• Name: homeobox D4; targeted mutation 1, Richard R Behringer
• MGI ID: MGI:2151488
• Synonyms: Hoxd-4^-
• Gene: Hoxd4 Location: Chr2:74552322-74559504 bp, + strand Genetic Position: Chr2, 44.13 cM, cytoband D
• Alliance: Hoxd4^tm1Bhr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:25267
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Insertion of a neomycin cassette into sequences encoding the homeodomain. RNAse protection assays did not detect any transcript from this allele in total RNA from E11 embryos or adult kidney or testis tissue derived from homozygous mice. (J:25267)

Expression

In Mice Carrying this Mutation:	12 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxd4 Mutation: 12 strains or lines available

References

• Original: J:25267 Horan GS, et al., Mutations in paralogous hox genes result in overlapping homeotic transformations of the axial skeleton: evidence for unique and redundant function. Dev Biol. 1995 MAY;169(1):359-372
• All: 6 reference(s)