Gna11^tm1Soff
Targeted Allele Detail

Summary

• Symbol: Gna11^tm1Soff
• Name: guanine nucleotide binding protein, alpha 11; targeted mutation 1, Stefan Offermanns
• MGI ID: MGI:2151589
• Synonyms: Galpha11-, Gna11^-
• Gene: Gna11 Location: Chr10:81364558-81380996 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Gna11^tm1Soff page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:49140
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129S7/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin cassette replaced exons 3, 4 and part of 5, which encodes the amino acids that contribute to the guanine nucleotide binding pocket. Western blot analysis on extracts of brain, spleen and testis tissues did not detect any protein expressed from this allele in homozyogous mice. (J:49140)

Expression

In Mice Carrying this Mutation:	37 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gna11 Mutation: 25 strains or lines available

Notes

ES cell line = AB1 (129S7/SvEvBrd-Hprt⁺) or JH1 (129S7/SvEvBrd).

References

• Original: J:49140 Offermanns S, et al., Embryonic cardiomyocyte hypoplasia and craniofacial defects in G alpha q/G alpha 11-mutant mice. EMBO J. 1998 Aug 3;17(15):4304-12
• All: 67 reference(s)