Hoxa1^tm3.1Mrc
Targeted Allele Detail

Summary

• Symbol: Hoxa1^tm3.1Mrc
• Name: homeobox A1; targeted mutation 3.1, Mario R Capecchi
• MGI ID: MGI:2151686
• Synonyms: Hoxa1^GFPlox
• Gene: Hoxa1 Location: Chr6:52132573-52135299 bp, - strand Genetic Position: Chr6, 25.4 cM
• Alliance: Hoxa1^tm3.1Mrc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50569
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Insertion of a eGFP gene in-frame to sequences encoding the Hoxa1 gene. An adjacent loxP-flanked neomycin cassette was removed via Cre-mediated recombination in mice in this derivative of Hoxa1^tm3Mrc. A Hoxa1-eGFP fusion protein is expressed from this allele in a pattern identical to that predicted by in situ hybridization analysis. (J:50569)

Disease models

Expression

In Mice Carrying this Mutation:	38 assay results
In Structures Affected by this Mutation:	15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxa1 Mutation: 14 strains or lines available

References

• Original: J:50569 Godwin AR, et al., Detection of targeted GFP-Hox gene fusions during mouse embryogenesis. Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13042-7
• All: 5 reference(s)