Hoxc13^tm3.1Mrc
Targeted Allele Detail

Summary

• Symbol: Hoxc13^tm3.1Mrc
• Name: homeobox C13; targeted mutation 3.1, Mario R Capecchi
• MGI ID: MGI:2151697
• Synonyms: Hoxc13^GFPlox
• Gene: Hoxc13 Location: Chr15:102829566-102837249 bp, + strand Genetic Position: Chr15, Syntenic
• Alliance: Hoxc13^tm3.1Mrc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50569
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: In-frame insertion of a eGFP gene into DNA sequences encoding the homeodomain. An adjacent loxP-flanked neomycin cassette was removed via Cre-mediated recombination. A Hoxc11-GFP fusion protein is expressed from this allele and is detected in the same pattern as was previously detected for this gene. (J:50569)

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxc13 Mutation: 15 strains or lines available

References

• Original: J:50569 Godwin AR, et al., Detection of targeted GFP-Hox gene fusions during mouse embryogenesis. Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13042-7
• All: 2 reference(s)