Hoxb2^tm1Mrc
Targeted Allele Detail

Summary

• Symbol: Hoxb2^tm1Mrc
• Name: homeobox B2; targeted mutation 1, Mario R Capecchi
• MGI ID: MGI:2151772
• Synonyms: hoxb-2^-
• Gene: Hoxb2 Location: Chr11:96242458-96244846 bp, + strand Genetic Position: Chr11, 59.85 cM
• Alliance: Hoxb2^tm1Mrc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:37682
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• A neomycin cassette was inserted into the sequences encoding the homeobox domain in exon 2. (J:37682)

Expression

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxb2 Mutation: 12 strains or lines available

References

• Original: J:37682 Barrow JR, et al., Targeted disruption of the Hoxb-2 locus in mice interferes with expression of Hoxb-1 and Hoxb-4. Development. 1996 Dec;122(12):3817-28
• All: 2 reference(s)