Hoxb3^tm1Mrc
Targeted Allele Detail

Summary

• Symbol: Hoxb3^tm1Mrc
• Name: homeobox B3; targeted mutation 1, Mario R Capecchi
• MGI ID: MGI:2151773
• Synonyms: Hoxb3-
• Gene: Hoxb3 Location: Chr11:96214152-96238756 bp, + strand Genetic Position: Chr11, 59.84 cM
• Alliance: Hoxb3^tm1Mrc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:45337
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 225 bp fragment of the gene encoding the entire homeobox domain was replaced with a neomycin cassette. (J:45337)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxb3 Mutation: 16 strains or lines available

References

• Original: J:45337 Manley NR, et al., Hox group 3 paralogous genes act synergistically in the formation of somitic and neural crest-derived structures. Dev Biol. 1997 Dec 15;192(2):274-88
• All: 7 reference(s)