Gna13^tm1Soff
Targeted Allele Detail

Summary

• Symbol: Gna13^tm1Soff
• Name: guanine nucleotide binding protein, alpha 13; targeted mutation 1, Stefan Offermanns
• MGI ID: MGI:2151775
• Synonyms: Galpha13^-
• Gene: Gna13 Location: Chr11:109253657-109292195 bp, + strand Genetic Position: Chr11, 71.88 cM
• Alliance: Gna13^tm1Soff page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50566
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing the first exon was replaced with a neomycin cassette. RT-PCR analysis did not detect a transcript produced from this allele in homozygous mice. (J:50566)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gna13 Mutation: 12 strains or lines available

References

• Original: J:50566 Offermanns S, et al., Vascular system defects and impaired cell chemokinesis as a result of Galpha13 deficiency. Science. 1997 Jan 24;275(5299):533-6
• All: 9 reference(s)