Hoxd11^tm1Ipc
Targeted Allele Detail

Summary

• Symbol: Hoxd11^tm1Ipc
• Name: homeobox D11; targeted mutation 1, Pierre Chambon
• MGI ID: MGI:2151798
• Synonyms: Hoxd-11^-
• Gene: Hoxd11 Location: Chr2:74509902-74517360 bp, + strand Genetic Position: Chr2, 44.13 cM
• Alliance: Hoxd11^tm1Ipc page

Anterior homeosis of sacral vertebrae of wild type and Hoxd11^tm1Ipc/Hoxd11^tm1Ipc mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:22289
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 633 bp genomic fragment including sequences in intron 1 through the 23rd codon of the homeobox sequence in exon 2 was deleted and replaced with a neomycin cassette. (J:22289)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxd11 Mutation: 14 strains or lines available

References

• Original: J:22289 Favier B, et al., Axial skeleton homeosis and forelimb malformations in Hoxd-11 mutant mice. Proc Natl Acad Sci U S A. 1995 Jan 3;92(1):310-4
• All: 4 reference(s)