Ahr^tm1Gonz
Targeted Allele Detail

Summary

• Symbol: Ahr^tm1Gonz
• Name: aryl-hydrocarbon receptor; targeted mutation 1, Frank J Gonzales
• MGI ID: MGI:2151800
• Synonyms: AhR^-
• Gene: Ahr Location: Chr12:35547978-35584988 bp, - strand Genetic Position: Chr12, 15.78 cM
• Alliance: Ahr^tm1Gonz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:25048
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exon 1 was replaced with a neomycin resistance gene. (J:25048)

Expression

In Structures Affected by this Mutation:

22 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Ahr^tm1Gonz

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ahr Mutation: 112 strains or lines available

References

• Original: J:25048 Fernandez-Salguero P, et al., Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor [see comments]. Science. 1995 May 5;268(5211):722-6
• All: 76 reference(s)