Ahr^tm1Gonz
Targeted Allele Detail

Summary

• Symbol: Ahr^tm1Gonz
• Name: aryl-hydrocarbon receptor; targeted mutation 1, Frank J Gonzales
• MGI ID: MGI:2151800
• Synonyms: AhR^-
• Gene: Ahr Location: Chr12:35547978-35584988 bp, - strand Genetic Position: Chr12, 15.78 cM
• Alliance: Ahr^tm1Gonz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:25048
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exon 1 was replaced with a neomycin resistance gene. (J:25048)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Ahr^tm1Gonz/Ahr^tm1Gonz	involves: 129S4/SvJae
hm2	Ahr^tm1Gonz/Ahr^tm1Gonz	involves: 129S4/SvJae * C57BL/6J
hm3	Ahr^tm1Gonz/Ahr^tm1Gonz	involves: 129S4/SvJae * C57BL/6N

Phenotypes:

Affected Systems	hm1	hm2	hm3
show or hide all annotated terms Sex:
cardiovascular system			√	√
abnormal blood vessel morphology			√	√
vascular smooth muscle hypertrophy			√	√
abnormal heart morphology			√	√
abnormal coronary artery morphology			√	√
enlarged heart			√	√
increased heart weight			√	√
cardiac fibrosis			√	√
heart inflammation			√	√
digestive/alimentary system			√	√
chronic diarrhea			√	√
abnormal colon morphology			√	√
rectal prolapse			√	√
abnormal stomach pyloric region morphology			√	√
gastric polyps			√	√
colitis			√	√
growth/size/body			√	√
enlarged heart			√	√
increased heart weight			√	√
weight loss			√	√
postnatal growth retardation			√	√
enlarged spleen			√	√
hematopoietic system			√	√
abnormal spleen morphology			√	√
enlarged spleen			√	√
abnormal spleen red pulp morphology			√	√
small spleen			√	√
spleen hypoplasia			√	√
decreased spleen white pulp amount			√	√
homeostasis/metabolism	√	√	√	√
abnormal thrombosis			√	√
abnormal atrial thrombosis			√	√
decreased susceptibility to xenobiotic induced morbidity/mortality		√
decreased physiological sensitivity to xenobiotic	√	√	√	√
immune system			√	√
abnormal spleen morphology			√	√
enlarged spleen			√	√
abnormal spleen red pulp morphology			√	√
small spleen			√	√
spleen hypoplasia			√	√
decreased spleen white pulp amount			√	√
increased inflammatory response			√	√
heart inflammation			√	√
colitis			√	√
bile duct inflammation			√	√
folliculitis			√	√
integument			√	√
abnormal coat/ hair morphology			√	√
abnormal auchene hair morphology			√	√
alopecia			√	√
abnormal hair shaft morphology			√	√
abnormal hair follicle morphology			√	√
folliculitis			√	√
dilated piliary canal			√	√
abnormal epidermal layer morphology			√	√
hypergranulosis			√	√
acanthosis			√	√
scaly skin			√	√
skin lesions			√	√
spontaneous skin ulceration			√	√
abnormal skin condition			√	√
thick skin			√	√
liver/biliary system			√	√
bile duct inflammation			√	√
abnormal liver morphology			√	√
abnormal hepatocyte morphology			√	√
decreased liver weight			√	√
increased hepatoma incidence			√	√
increased liver adenoma incidence			√	√
liver fibrosis			√	√
abnormal liver physiology			√	√
mortality/aging		√	√	√
decreased susceptibility to xenobiotic induced morbidity/mortality		√
premature death			√	√
postnatal lethality, incomplete penetrance			√	√
muscle			√	√
vascular smooth muscle hypertrophy			√	√
neoplasm			√	√
increased hepatoma incidence			√	√
increased liver adenoma incidence			√	√
reproductive system	N	√	√	√
reproductive system phenotype	N
abnormal uterus morphology			√
reduced female fertility			√
decreased litter size		√	√	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

22 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Ahr^tm1Gonz

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ahr Mutation: 112 strains or lines available

References

• Original: J:25048 Fernandez-Salguero P, et al., Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor [see comments]. Science. 1995 May 5;268(5211):722-6
• All: 77 reference(s)