Msh2^tm1Rak
Targeted Allele Detail

Summary

• Symbol: Msh2^tm1Rak
• Name: mutS homolog 2; targeted mutation 1, Raju Kucherlapati
• MGI ID: MGI:2151801
• Synonyms: Msh2^deltaN7
• Gene: Msh2 Location: Chr17:87979960-88031141 bp, + strand Genetic Position: Chr17, 57.87 cM
• Alliance: Msh2^tm1Rak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64667
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 7 was replaced with a vector, inserted in reverse orientation, containing the neomycin resistance gene. (J:64667)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Msh2^tm1Rak

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Msh2 Mutation: 95 strains or lines available

References

• Original: J:64667 Smits R, et al., Somatic apc mutations are selected upon their capacity to inactivate the beta-catenin downregulating activity. Genes Chromosomes Cancer. 2000 Nov;29(3):229-39
• All: 16 reference(s)