Msh6^tm1Htr
Targeted Allele Detail

Summary

• Symbol: Msh6^tm1Htr
• Name: mutS homolog 6; targeted mutation 1, Hein te Riele
• MGI ID: MGI:2151803
• Gene: Msh6 Location: Chr17:88282490-88298320 bp, + strand Genetic Position: Chr17, 57.87 cM
• Alliance: Msh6^tm1Htr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:59561
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Part of exon 4 was replaced with a vector containing the puromycin resistance gene. (J:59561)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Msh6^tm1Htr

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Msh6 Mutation: 52 strains or lines available

References

• Original: J:59561 de Wind N, et al., HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions. Nat Genet. 1999 Nov;23(3):359-62
• All: 6 reference(s)