Hoxd8^tm1Jdes
Targeted Allele Detail

Summary

• Symbol: Hoxd8^tm1Jdes
• Name: homeobox D8; targeted mutation 1, Jacqueline Deschamps
• MGI ID: MGI:2151815
• Gene: Hoxd8 Location: Chr2:74534973-74538277 bp, + strand Genetic Position: Chr2, 44.13 cM, cytoband D
• Alliance: Hoxd8^tm1Jdes page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:68720
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• A neomycin cassette was inserted into the sequences in exon 2 which encode the homeodomain. (J:68720)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxd8 Mutation: 11 strains or lines available

References

• Original: J:68720 van den Akker E, et al., Axial skeletal patterning in mice lacking all paralogous group 8 Hox genes. Development. 2001 May;128(10):1911-21
• All: 1 reference(s)