Pcdh15^av-Tg2742Rpw
Transgenic Allele Detail

Summary

• Symbol: Pcdh15^av-Tg2742Rpw
• Name: protocadherin 15; transgenic, nonhomologous insert 2742, Richard P Woychik
• MGI ID: MGI:2151877
• Synonyms: av-Tg, av^TgN2742Rpw, Pcdh15^av-Tg, TgN(Imw)2724Rpw
• Gene: Pcdh15 Location: Chr10:72935174-74485569 bp, + strand Genetic Position: Chr10, 37.43 cM
• Alliance: Pcdh15^av-Tg2742Rpw page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic
• Mutation: Insertion
• Mutation details: A construct consisting of a human beta-actin promoter driving expression of a rat lectin cDNA was injected into fertilized eggs. The construct integrated in multiple tandem copies into the coding region of the Pcdh15 gene, disupting the coding seqence for the fourth cdh domain. Truncated transcripts are produced from this allele that are smaller than normal size due to the SV40 poly(A) site that is present in the transgene. (J:66738)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pcdh15 Mutation: 135 strains or lines available

References

• Original: J:56493 Alagramam KN, et al., A new mouse insertional mutation that causes sensorineural deafness and vestibular defects. Genetics. 1999 Aug;152(4):1691-9
• All: 9 reference(s)