Alx3^tm1Hubr
Targeted Allele Detail

Summary

• Symbol: Alx3^tm1Hubr
• Name: aristaless-like homeobox 3; targeted mutation 1, Hubrecht Institute
• MGI ID: MGI:2151910
• Synonyms: Alx3-, Alx3-LacZ, Alx3^tm1Fme
• Gene: Alx3 Location: Chr3:107502347-107513092 bp, + strand Genetic Position: Chr3, 46.83 cM
• Alliance: Alx3^tm1Hubr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71880
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An in frame lacZ-loxP-PGK-TKNEOpA-loxP cassette 28bp upstream of the homeobox in exon 2 replaced sequences encoding the conserved protein domains. Analysis of beta-galactosidase expression in heterozygous embryos of E9.5 to E12.5 showed essentially no differences with endogenous Alx3 expression. (J:71880)

Expression

In Mice Carrying this Mutation:	29 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Alx3 Mutation: 14 strains or lines available

References

• Original: J:71880 Beverdam A, et al., Severe nasal clefting and abnormal embryonic apoptosis in Alx3/Alx4 double mutant mice. Development. 2001 Oct;128(20):3975-86
• All: 7 reference(s)