Tg(APPV717F)109Ili
Transgene Detail
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Symbol: |
Tg(APPV717F)109Ili |
Name: |
transgene insertion 109, Ivan Lieberburg |
MGI ID: |
MGI:2151935 |
Synonyms: |
APPInd, APPV717F, hAPP+, hbeta-APP, PDAPP, PDAPP+, PDAPP-109, PD-APP transgenic, PDAPP-V717F, PDGF-hAPP(V717F), Tg(APP*Ind)109Ili |
Transgene: |
Tg(APPV717F)109Ili Location: unknown
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Alliance: |
Tg(APPV717F)109Ili page
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Strain of Origin: |
Not Specified
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Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(APPV717F)109Ili expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
APP (351) |
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The gene encodes the V717F mutation. |
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Mutation details: Overexpression of a human APP (hAPP) minigene encoding the APP717V to F mutation associated with familial Alzheimer's Disease. The construct contained APP introns 6 - 8, allowing alternative splicing of exons 7 and 8. The transgene utilizes a platelet-derived growth factor promoter (PDGF-b) and the three major splicing variants of hAPP mRNA were expressed in transgenic mice. As determined by RNAse protection, line 109 expressed ~ 18-fold more APP than previously described neuron-specific enolase (NSE)-promoter-driven APP transgenes.
(J:23080, J:100980)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:23080 Games D, et al., Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein [see comments]. Nature. 1995 Feb 9;373(6514):523-7 |
All: |
110 reference(s) |
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