Dnah1^tm1Ihgg
Targeted Allele Detail

Summary

• Symbol: Dnah1^tm1Ihgg
• Name: dynein, axonemal, heavy chain 1; targeted mutation 1, Institut fur Humangenetik
• MGI ID: MGI:2151944
• Synonyms: MDHC7^-
• Gene: Dnah1 Location: Chr14:30982332-31045853 bp, - strand Genetic Position: Chr14, Syntenic
• Alliance: Dnah1^tm1Ihgg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:69800
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Four exons encoding the P1-loop region are replaced by a neomycin cassette. Northern blot analysis did not detect a transcript produced from this allele and western blot analysis did not detect DNAHC1 protein in extracts of testis or oviducts from homozygous mice. (J:69800)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dnah1 Mutation: 168 strains or lines available

References

• Original: J:69800 Neesen J, et al., Disruption of an inner arm dynein heavy chain gene results in asthenozoospermia and reduced ciliary beat frequency. Hum Mol Genet. 2001 May 15;10(11):1117-28
• All: 2 reference(s)