Dock2^tm1Tsas
Targeted Allele Detail

Summary

• Symbol: Dock2^tm1Tsas
• Name: dedicator of cyto-kinesis 2; targeted mutation 1, Takehiko Sasazuki
• MGI ID: MGI:2152031
• Synonyms: Dock2^-
• Gene: Dock2 Location: Chr11:34176815-34674719 bp, - strand Genetic Position: Chr11, 19.68 cM, cytoband A5
• Alliance: Dock2^tm1Tsas page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71005
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced 3.1kb of sequence that includes part of exon 3 through exon 5. Western blot analysis did not detect protein in the spleen and thymus of homozygous mice. (J:71005)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dock2 Mutation: 143 strains or lines available

References

• Original: J:71005 Fukui Y, et al., Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration. Nature. 2001 Aug 23;412(6849):826-31
• All: 31 reference(s)