Neurl1a^tm1Ynj
Targeted Allele Detail

Summary

• Symbol: Neurl1a^tm1Ynj
• Name: neuralized E3 ubiquitin protein ligase 1A; targeted mutation 1, Yuh Nung Jan
• MGI ID: MGI:2152037
• Synonyms: m-neu1
• Gene: Neurl1a Location: Chr19:47167259-47247880 bp, + strand Genetic Position: Chr19, 39.39 cM
• Alliance: Neurl1a^tm1Ynj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71088
• Parent Cell Line: JM-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The last three exons of the gene were replaced by a neomycin cassette. Northern blot analysis demonstrated an absence of Neur1 mRNA in RNA derived from brains of homozygous mice. (J:71088)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Neurl1a Mutation: 20 strains or lines available

References

• Original: J:71088 Ruan Y, et al., Ethanol hypersensitivity and olfactory discrimination defect in mice lacking a homolog of Drosophila neuralized. Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9907-12
• All: 2 reference(s)