Cul1^tm1Rsjo
Targeted Allele Detail

Summary

• Symbol: Cul1^tm1Rsjo
• Name: cullin 1; targeted mutation 1, Randall S Johnson
• MGI ID: MGI:2152042
• Synonyms: Cul1-
• Gene: Cul1 Location: Chr6:47430516-47503078 bp, + strand Genetic Position: Chr6, 22.9 cM, cytoband B3
• Alliance: Cul1^tm1Rsjo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57767
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced the ATG initiation codon and 1kb of 5' flanking sequence. Immunohistochemical analysis detected no expression of protein from this allele in homozygous mice. (J:57767)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cul1 Mutation: 58 strains or lines available

References

• Original: J:57767 Dealy MJ, et al., Loss of Cul1 results in early embryonic lethality and dysregulation of cyclin E. Nat Genet. 1999 Oct;23(2):245-8
• All: 1 reference(s)