Prkce^tm1Msg
Targeted Allele Detail

Summary

• Symbol: Prkce^tm1Msg
• Name: protein kinase C, epsilon; targeted mutation 1, Robert Messing
• MGI ID: MGI:2152043
• Synonyms: PKC-epsilon-, PKCepsilon-
• Gene: Prkce Location: Chr17:86475213-86965347 bp, + strand Genetic Position: Chr17, 56.74 cM
• Alliance: Prkce^tm1Msg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57887
• Parent Cell Line: RF8 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 1.2 kb of this gene including the translation initiation site was deleted via homologous recombination with a neo-derived targeting vector. Western blot indicated homozygous mutant animals did not express protein in dorsal root ganglion. (J:57887)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prkce Mutation: 40 strains or lines available

References

• Original: J:57887 Khasar SG, et al., A novel nociceptor signaling pathway revealed in protein kinase C epsilon mutant mice. Neuron. 1999 Sep;24(1):253-60
• All: 52 reference(s)