Ptf1a^tm1Pkwe
Targeted Allele Detail

Summary

• Symbol: Ptf1a^tm1Pkwe
• Name: pancreas specific transcription factor, 1a; targeted mutation 1, Peter K Wellauer
• MGI ID: MGI:2152066
• Synonyms: p48 -
• Gene: Ptf1a Location: Chr2:19450474-19452312 bp, + strand Genetic Position: Chr2, 13.37 cM, cytoband A2
• Alliance: Ptf1a^tm1Pkwe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:51571
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance gene cassette was inserted into exon 1 upstream of the sequences encoding the bHLH region. RT-PCR analysis failed to detect any mRNA derived from this mutant allele in homozygous mice. (J:51571)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptf1a Mutation: 31 strains or lines available

References

• Original: J:51571 Krapp A, et al., The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas. Genes Dev. 1998 Dec 1;12(23):3752-63
• All: 5 reference(s)