Itpka^tm1Hssh
Targeted Allele Detail

Summary

• Symbol: Itpka^tm1Hssh
• Name: inositol 1,4,5-trisphosphate 3-kinase A; targeted mutation 1, Hee-Sup Shin
• MGI ID: MGI:2152168
• Gene: Itpka Location: Chr2:119572818-119581734 bp, + strand Genetic Position: Chr2, 59.97 cM
• Alliance: Itpka^tm1Hssh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:51150
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin cassette was inserted into the sequence at position 389 from the translation start codon. Northern blot analysis on RNA derived from brain of homozygous mice failed to detect a transcript produced from this allele, and western blot analysis demonstrated that no ITPKA protein is produced in homozygous mice. (J:51150)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itpka Mutation: 11 strains or lines available

References

• Original: J:51150 Jun K, et al., Enhanced hippocampal CA1 LTP but normal spatial learning in inositol 1,4,5-trisphosphate 3-kinase(A)-deficient mice. Learn Mem. 1998 Sep-Oct;5(4-5):317-30
• All: 3 reference(s)