Mttp^tm1Sgy
Targeted Allele Detail

Summary

• Symbol: Mttp^tm1Sgy
• Name: microsomal triglyceride transfer protein; targeted mutation 1, Stephen G Young
• MGI ID: MGI:2152201
• Gene: Mttp Location: Chr3:137795616-137849179 bp, - strand Genetic Position: Chr3, 64.06 cM
• Alliance: Mttp^tm1Sgy page

Phenotype of Mttp^tm1Sgy/Mttp^tm1Sgy and wild-type embryos at E9.5

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:48934
• Parent Cell Line: RF8 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An in-frame GFP gene and neomycin cassette replaced most of exon 1. No mRNA was detected by RNase protection assay in samples derived from liver and yolk sac from homozygous mice. (J:48934)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mttp Mutation: 53 strains or lines available

References

• Original: J:48934 Raabe M, et al., Knockout of the abetalipoproteinemia gene in mice: reduced lipoprotein secretion in heterozygotes and embryonic lethality in homozygotes. Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8686-91
• All: 4 reference(s)