Mttp^tm2Sgy
Targeted Allele Detail

Summary

• Symbol: Mttp^tm2Sgy
• Name: microsomal triglyceride transfer protein; targeted mutation 2, Steven G Young
• MGI ID: MGI:2152202
• Synonyms: Mttp^fl
• Gene: Mttp Location: Chr3:137795616-137849179 bp, - strand Genetic Position: Chr3, 64.06 cM
• Alliance: Mttp^tm2Sgy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:54612
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette flanked by loxP sites was inserted into intron 1. An additional loxP site was inserted 2.5 kb upstream of the promoter and exon 1. (J:54612)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Mttp Mutation: 53 strains or lines available

References

• Original: J:54612 Raabe M, et al., Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice. J Clin Invest. 1999 May;103(9):1287-98
• All: 41 reference(s)