Esr2^tm1Unc
Targeted Allele Detail

Summary

• Symbol: Esr2^tm1Unc
• Name: estrogen receptor 2 (beta); targeted mutation 1, University of North Carolina
• MGI ID: MGI:2152217
• Synonyms: BERKO, BERKOChapel Hill, beta-ERKO, betaERKO, Erb-, ERbeta-, ERbetaKO
• Gene: Esr2 Location: Chr12:76167193-76224033 bp, - strand Genetic Position: Chr12, 33.52 cM, cytoband D1-D3
• Alliance: Esr2^tm1Unc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:51663
• Parent Cell Line: BK4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into exon 3 of the gene, introducing a stop codon and resulting in premature termination of translation of the Esr2 mRNA. Immunocytochemistry of ovary from homozygous mutant females showed no detectable Esr2 protein. (J:51663)

Expression

In Mice Carrying this Mutation:	27 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	39 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Esr2^tm1Unc

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Esr2 Mutation: 36 strains or lines available

Notes

ES cell line = BK4, which is derived from a subclone of E14TG2a.

References

• Original: J:51663 Krege JH, et al., Generation and reproductive phenotypes of mice lacking estrogen receptor beta. Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15677-82
• All: 199 reference(s)