Apoe^tm1Lmh
Targeted Allele Detail

Summary

• Symbol: Apoe^tm1Lmh
• Name: apolipoprotein E; targeted mutation 1, Louis M Havekes
• MGI ID: MGI:2152302
• Synonyms: apoe-, Apoe⁰
• Gene: Apoe Location: Chr7:19430034-19433113 bp, - strand Genetic Position: Chr7, 9.94 cM
• Alliance: Apoe^tm1Lmh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:22347
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A hygromycin B resistance cassette replaced exons 1, 2, and part of 3 of the gene. Northern blots of liver from homozygous mutant mice showed no detectable transcript. Western blots from homozygous mutant mice showed no detectable protein. (J:22347)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apoe Mutation: 158 strains or lines available

References

• Original: J:22347 van Ree JH, et al., Diet-induced hypercholesterolemia and atherosclerosis in heterozygous apolipoprotein E-deficient mice. Atherosclerosis. 1994 Nov;111(1):25-37
• All: 37 reference(s)