Taf4b^tm1Rtj
Targeted Allele Detail

Summary

• Symbol: Taf4b^tm1Rtj
• Name: TATA-box binding protein associated factor 4b; targeted mutation 1, Robert Tjian
• MGI ID: MGI:2152347
• Synonyms: TAF4B^-, TAFII105
• Gene: Taf4b Location: Chr18:14916302-15033416 bp, + strand Genetic Position: Chr18, 8.28 cM
• Alliance: Taf4b^tm1Rtj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71679
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Half of exon "h" located in the 3' end of the gene was replaced with a neomycin cassette inserted in reverse transcriptional orientation to the gene. Western blot analysis of B cell extracts derived from mice of each genotype confirmed that the protein was not expressed in homozygous mice.

Expression

In Mice Carrying this Mutation:	4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Taf4b Mutation: 50 strains or lines available

References

• Original: J:71679 Freiman RN, et al., Requirement of tissue-selective TBP-associated factor TAFII105 in ovarian development. Science. 2001 Sep 14;293(5537):2084-7
• All: 11 reference(s)