Nrl^tm1Asw
Targeted Allele Detail

Summary

• Symbol: Nrl^tm1Asw
• Name: neural retina leucine zipper gene; targeted mutation 1, Anand Swaroop
• MGI ID: MGI:2152376
• Synonyms: cone-full, Nrl-
• Gene: Nrl Location: Chr14:55756973-55762438 bp, - strand Genetic Position: Chr14, 28.19 cM
• Alliance: Nrl^tm1Asw page

Adult rods are reprogrammed into cone-like cells in Nrl^tm1.1Jcco/Nrl^tm1.1Jcco and Nrl^tm1Asw/Nrl^tm1Asw retinas

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71808
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin resistance cassette replaced the entire coding region (exons 2 and 3). Immunoblot analysis did not detect protein in retina from 10 day old homozygous mutant mice. RT-PCR studies of retina from 10 day old homozygous mutant mice did not detect mRNA. (J:78692)

Disease models

Expression

In Mice Carrying this Mutation:	52143 assay results 9 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nrl Mutation: 18 strains or lines available

References

• Original: J:71808 Swain PK, et al., Multiple phosphorylated isoforms of NRL are expressed in rod photoreceptors. J Biol Chem. 2001 Sep 28;276(39):36824-30
• All: 123 reference(s)